Bayer Presents Latest Xofigo (radium Ra 223 dichloride) Injection Research at ASCO GU 2016

WHIPPANY, N.J., Jan. 4, 2016 Bayer announced today that new research findings on Xofigo^® (radium Ra 223 dichloride) injection will be presented at the 2016 Genitourinary Cancers Symposium of the American Society of Clinical Oncology (ASCO GU) taking place January 7 – 9 in San Francisco.

"The data being presented at ASCO GU underscore Bayer's commitment to explore the full potential of radium-223 dichloride for men with castration-resistant prostate cancer, symptomatic bone metastases and no known visceral metastatic disease," said Dario Mirski, M.D., Bayer's vice president and head of U.S. Medical Affairs. "The impact of advanced prostate cancer can be devastating with about 90 percent of men living with advanced prostate developing bone metastases. Our research efforts are driven by a commitment to find treatment approaches that can benefit these patients."

Among data being presented are the first safety and efficacy findings of radium-223 dichloride re-treatment in patients with metastatic castration-resistant prostate cancer and bone metastases. The safety and efficacy of radium-223 dichloride beyond six injections has not been established.

Notable studies evaluating radium-223 dichloride at ASCO GU 2016 are listed below.

Radium Ra 223 Dichloride (radium-223)

About Xofigo^® (radium Ra 223 dichloride) Injection

Xofigo is indicated for the treatment of patients with castration-resistant prostate cancer, symptomatic bone metastases and no known visceral metastatic disease.

Xofigo is an alpha particle-emitting radioactive therapeutic agent with an anti-tumor effect on bone metastases. The active ingredient in Xofigo is the alpha particle-emitting isotope radium-223, which mimics calcium and forms complexes with the bone mineral hydroxyapatite at areas of increased bone turnover, such as bone metastases. The high linear energy transfer of Xofigo may cause double-strand DNA breaks in adjacent cells, resulting in an anti-tumor effect on bone metastases. The alpha particle range from radium Ra 223 dichloride is less than 100 micrometers which may limit the damage to the surrounding normal tissue.¹

Important Safety Information for Xofigo^® (radium Ra 223 dichloride) Injection

For full prescribing information visithttp://labeling.bayerhealthcare.com/html/products/pi/Xofigo_PI.pdf.

About Oncology at Bayer

Bayer is committed to delivering science for a better life by advancing a portfolio of innovative treatments.The oncology franchise at Bayer now includes three oncology products and several other compounds in various stages of clinical development. Together, these products reflect the company's approach to research, which prioritizes targets and pathways with the potential to impact the way that cancer is treated.

Bayer: Science For A Better Life

Bayer is a global enterprise with core competencies in the Life Science fields of health care and agriculture. Its products and services are designed to benefit people and improve their quality of life. At the same time, the Group aims to create value through innovation, growth and high earning power. Bayer is committed to the principles of sustainable development and to its social and ethical responsibilities as a corporate citizen. In fiscal 2014, the Group employed around 119,000 people and had sales of EUR 42.2 billion. Capital expenditures amounted to EUR 2.5 billion, R&D expenses to EUR 3.6 billion. These figures include those for the high-tech polymers business, which was floated on the stock market as an independent company named Covestro on October 6, 2015. For more information, go to www.bayer.us.

© 2016 Bayer
BAYER, the Bayer Cross and Xofigo are registered trademarks of Bayer.

Forward-Looking Statement
This news release may contain forward-looking statements based on current assumptions and forecasts made by Bayer Group or subgroup management. Various known and unknown risks, uncertainties and other factors could lead to material differences between the actual future results, financial situation, development or performance of the company and the estimates given here. These factors include those discussed in Bayer's public reports which are available on the Bayer website at www.bayer.com. The company assumes no liability whatsoever to update these forward-looking statements or to conform them to future events or developments.

1.XOFIGO^® (radium Ra 223 dichloride) [Prescribing Information]. Wayne, NJ: Bayer HealthCare Pharmaceuticals, May 2013.

PP-600-US-1705